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KMID : 0380420230470010013
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Journal of Prventive Veterinary Medicine
2023 Volume.47 No. 1 p.13 ~ p.18
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Subacute oral toxicity of Dendropanax morbiferus H.Lev leaf extracts in Sprague-Dawley rats
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Park Ji-Yong
Cho Chang-Soo
Song Jun-Ho
Park Kwang-Il
Jin Yeung-Bae
Kim Woo-Hyun
Kim Suk
Lee Hu-Jang
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Abstract
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This study examined the subacute oral toxicity of Dendropanax morbiferus H.Lev leaves hot-water extracts (DMWE) using male and female Spargue-Dawley rats. Rats were orally administered the DMWE at dose levels of 0, 250, 500, 1,000, and 2,000 mg/kg body weight (BW) for four weeks. For experimental period, clinical signs and the number of deaths were examined, and feed intake and BW of all experimental animals were measured once a week for four weeks. At the end of the experiment, blood samples were collected from all rats, and all animals were euthanized and autopsies were performed to collect major organs. No dead animals were found during the experimental period. In addition, no differences were found between control and DMWE-treated groups in feed intakes, BW changes, organ weights, clinical signs, hematological parameters, and serum biochemical parameters. The results of this study provided evidence that oral administration of DMWE at the dose of 2,000 mg/kg BW is safe in rats and may not exert severe toxic effects.
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KEYWORD
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Dendropanax morbiferus leaf, subacute oral toxicity, rats
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